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Коллоидный журнал, 2023, T. 85, № 5, стр. 682-704

Биосовместимые гидрогели на основе биоразлагаемых полиэфиров и их сополимеров

Ю. С. Фомина 1, А. С. Семкина 1, 2, Ю. Д. Загоскин 1, *, М. М. Алексанян 3, С. Н. Чвалун 1, 2, Т. Е. Григорьев 1

1 Федеральное государственное бюджетное учреждение “Национальный исследовательский центр “Курчатовский институт”
123182 Москва, пл. Академика Курчатова, 1, Россия

2 Федеральное государственное бюджетное учреждение науки Институт синтетических полимерных материалов имени Н.С. Ениколопова Российской академии наук
117393 Москва, Профсоюзная ул., 70/2, Россия

3 Федеральное государственное бюджетное научное учреждение “Российский научный центр хирургии имени академика Б.В. Петровского”, ГСП-1
119991 Москва, Абрикосовский пер., 2, Россия

* E-mail: zagos@inbox.ru

Поступила в редакцию 26.06.2023
После доработки 03.08.2023
Принята к публикации 03.08.2023

Аннотация

Гидрогели на основе полиэтиленгликоля достаточно давно зарекомендовали себя в качестве перспективных материалов для различных биомедицинских технологий. В обзоре рассмотрены системы на основе наиболее распространeнных и изученных сополимеров полиэтиленгликоля и биоразлагаемых полиэфиров лактида и гликолида. Показаны традиционные и современные подходы синтеза сополимеров и получения гидрогелей на их основе, отражены исследования структуры и свойств материалов, а также основные направления применения данных изделий на практике.

Ключевые слова: гидрогели, амфифильные блок-сополимеры, самоорганизация, полилактид, полилактид-со-гликолид, полиэтиленгликоль

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