Журнал высшей нервной деятельности им. И.П. Павлова, 2021, T. 71, № 6, стр. 803-819

Исследование полиморфизма 5-HTTLPR гена транспортера серотонина (обзор литературы)

Е. А. Прошина 1*, А. В. Бочаров 12, А. Н. Савостьянов 123, Г. Г. Князев 1

1 Научно-исследовательский институт нейронаук и медицины
Новосибирск, Россия

2 Новосибирский государственный университет
Новосибирск, Россия

3 Федеральный исследовательский центр институт цитологии и генетики СО РАН
Новосибирск, Россия

* E-mail: proshinaea@physiol.ru

Поступила в редакцию 05.03.2021
После доработки 24.04.2021
Принята к публикации 26.04.2021

Аннотация

Полиморфизм гена транспортера серотонина 5-HTTLPR является одним из самых изучаемых маркеров серотонинергической системы. Научный интерес к его изучению обусловлен тем, что во многих работах была показана связь короткого аллеля (S) с развитием ряда психических заболеваний. В ряде работ также показано, что разные аллели 5-HTTLPR ассоциированы с разными паттернами биоэлектрической активности мозга в условиях покоя или при выполнении тестовых заданий. Однако, несмотря на достаточно большое количество исследований этого маркера, их результаты зачастую противоречат друг другу. Возможными причинами несогласованности результатов могут являться игнорирование сложной структуры гена SLC6A4, неоднородность выборок, а также разница используемых методик. Цель нашей работы состоит в том, чтобы на основе обзора литературы провести комплексный анализ психологических, поведенческих, генетических и нейрофизиологических данных, что позволит обобщить эффекты, связанные с полиморфизмом 5-HTTLPR, а также, по крайней мере отчасти, объяснить неоднозначность полученных разными авторами результатов.

Ключевые слова: полиморфные варианты гена транспортера серотонина, 5-HTTLPR, ЭЭГ, фМРТ, личность

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