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Цитология, 2023, T. 65, № 6, стр. 557-572

Обзор локальных клеточно-молекулярных процессов регенерации костной ткани, индуцированных кальцийфосфатными материалами

Л. А. Мирошниченко 1, Т. Ю. Полякова 2, Л. С. Литвинова 1, *, И. А. Хлусов 1

1 Лаборатория клеточных и микрофлюидных технологий, Сибирский государственный медицинский университет
634050 Томск, Россия

2 Кафедра нормальной физиологии, Сибирский государственный медицинский университет
634050 Томск, Россия

* E-mail: larisalitvinova@yandex.ru

Поступила в редакцию 20.06.2023
После доработки 01.08.2023
Принята к публикации 04.08.2023

Аннотация

Одной из ведущих причин госпитализации, инвалидизации и смертности 50% женщин и 20% мужчин в возрастной группе старше 50 лет являются переломы костей и их осложнения, обусловленные заболеваниями опорно-двигательной системы. Активный поиск решения проблемы, связанной с ограничениями применения в клинике ауто-, алло- и ксенотрансплантатов, для замещения костных дефектов, инициировал развитие регенеративного подхода, основанного на постепенном замещении искусственного материала растущей костной тканью. Перспективными в этом отношении являются материалы на основе фосфатов кальция, выполняющие роль активного источника химических элементов (кальций, фосфор и др.), способные оптимизировать процесс срастания костного дефекта и обеспечить замену имплантата новой костной тканью. В представленном обзоре обобщены данные из литературы о локальной биологической активности, клетках-мишенях и молекулярных эффектах фосфатов кальция. Показано, что кальцийфосфатные материалы биосовместимы, способны адсорбировать регуляторные белки и клетки, оказывая влияние на их генетический и секреторный аппарат и запуская процесс дифференцировки МСК в остеогенном направлении. При этом успешная реализация локальных механизмов остеоинтеграции на границе раздела кость–имплантат снижает риск перипротезной инфекции и отторжения искусственных изделий. Дальнейшее изучение и использование кальцийфосфатных материалов позволит осуществить значительный прорыв в решении современных проблем регенерации костной ткани, связанный с точным (цифровым) биоинженерным подходом на основе аддитивных технологий и искусственного интеллекта.

Ключевые слова: кальцийфосфатные материалы, остеиндукция, остеогенные клетки, остеогенез, регенерация, мезенхимные стволовые клетки, клеточно-молекулярные механизмы

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