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Цитология, 2023, T. 65, № 5, стр. 407-419

Функциональные взаимодействия BAF и LEM-белков в процессах формирования половых клеток

И. О. Боголюбова 1, Д. С. Боголюбов 1, *

1 Институт цитологии РАН
194064 Санкт-Петербург, Россия

* E-mail: dbogol@mail.ru

Поступила в редакцию 27.04.2023
После доработки 27.05.2023
Принята к публикации 12.06.2023

Аннотация

Восстановление структуры ядра после деления клетки требует особых взаимодействий между интегральными белками внутренней ядерной мембраны, имеющими особый LEM-домен (LEMD), белками ядерной ламины (ламинами) и консервативным белком BAF, который выступает в качестве центрального звена в этих взаимодействиях, обеспечивающих топологические взаимоотношения хроматина и ядерной оболочки. Динамические преобразования этих белковых ансамблей в митотическом цикле детально охарактеризованы на молекулярном уровне, однако меньшее внимание уделяется формирующимся половым клеткам, претерпевающим мейотические деления, несмотря на то, что их ядра (особенно в случае диплотенных ооцитов) по своей структуре существенно отличаются от соматических клеток. В настоящем обзоре обобщены пока еще относительно немногочисленные экспериментальные данные, доказывающие значимость функциональных взаимодействий BAF и LEMD-белков для формирования гамет, начиная с выделения клеток зародышевой линии и заканчивая превращением гаплоидных сперматид в морфологически зрелые сперматозоиды.

Ключевые слова: ядерная архитектура, ядерная оболочка, гаметогенез, мейоз, клетки зародышевой линии, BAF, LEMD-белки, VRK1

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