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  4. T. 78, № 8, 2023

Журнал аналитической химии, 2023, T. 78, № 8, стр. 675-689

Белковые молекулы: шаблоны и матрицы в молекулярном импринтинге

П. С. Пиденко a, К. Ю. Пресняков a, Н. А. Бурмистрова a, *

a Саратовский государственный университет им. Н.Г. Чернышевского, Институт химии
410012 Саратов, ул. Астраханская, 83, Россия

* E-mail: naburmistrova@mail.ru

Поступила в редакцию 07.12.2022
После доработки 04.02.2023
Принята к публикации 09.02.2023

Аннотация

В обзоре рассмотрены вопросы молекулярного импринтинга с участием белковых молекул. Проведен анализ работ, опубликованных за последние пять лет в области биоимпринтинга и посвященных определению биомолекул, а также усилению ферментативной активности. Основное внимание уделено импринтингу белковых молекул как методу модификации структуры белковой молекулы за счет образования сайтов связывания в присутствии субстратов (белковыми молекулами с молекулярным отпечатками или импринтированными белками). Показана перспективность импринтинга белковых молекул при решении аналитических задач. Обсуждена неоднозначная трактовка термина “биоимпринтинг” при решении различных задач.

Ключевые слова: биоимпринтинг, молекулярно импринтированные полимеры, импринтированные белки, белки с молекулярными отпечатками, ферментативная активность, биосенсоры.

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